6:30-7 AM
Morning Coffee

7-8 AM
RISK FACTORS FOR ATRIAL FIBRILLATION - PATHOPHYSIOLOGY, CLINICAL IMPACT AND THERAPEUTIC STRATEGIES
Chair: Paul Wang, MD
All talks 10 minutes & 5 minutes Q&A

AF Under Age 40 - Genetic Testing Before Ablation?
Patrick Ellinor, MD, PhD

Sleep Apnea and AF: Where Do We Stand? - Practical Advice for Clinicians
Suneet Mittal, MD

Aggressive Weight Loss as Adjunctive Therapy for AF - Rationale, Clinical Data and Future Clinical Trials
Paul Wang, MD

Inflammation and AF: Overview and Potential Novel Therapeutic Target 2-HOBA
Gregory Michaud, MD

8-8:10 AM
Break

8:10-10 AM
SPOTLIGHT SESSION: Early Stage and Emerging New Technologies and Drugs in Cardiac EP
NON-CME
Chair: Jeremy Ruskin, MD
All talks 5 minutes

Presenters:

Ablacon, Vivek Reddy, MD
Acesion Pharma, A. John Camm, MD
BioSig Technologies , Andrea Natale, MD
CardioNXT, Jacob Koruth, MD
Cardiva Medical, Suneet Mittal, MD
CathVision, Pierre Jais, MD
Circle Cardiovascular Imaging, Saman Nazarian, MD
InCarda Therapeutics, Jeremy Ruskin, MD
inHEART, Pierre Jais, MD
Javelin Medical, Stuart Connolly, MD
Kardium, Hans Kottkamp, MD
LuxMed Systems, Benedict Glover, MD
Manual Surgical Sciences, Mark Marieb, MD
ReCor Medical, Vivek Reddy, MD
Sig.Num, Philippe Genereux, MD
Volta Medical, Jerome Kalifa, MD, PhD
Regulatory Approaches to Facilitate Early Stage Device Innovation, Aneesh Deoras, BS, MSE

10-10:30 AM
Continental Breakfast and Exhibits

10:30 AM-Noon
NOVEL TECHNIQUES AND TECHNOLOGIES FOR CATHETER ABLATION OF AF
Sponsored Session (Non-CME) - Abbott Medical
Moderator: Roger Winkle, MD
All talks 10 minutes with Q&A during panel discussion

High Density Grid and Overcoming Bipolar Blindness to Map AF and Atrial Flutter
Roger Winkle, MD

Elimination of All PVI Gaps: One Year Outcomes Using HD Mapping to Keep Redo Rates Below 10%
John Day, MD

Using HD Grid to Map Voltage and Drivers in Atrial Fibrillation
John Hummel, MD

The Hospital Economics of AF Ablation
Srijoy Mahapatra, MD

Case Presentation
Monica Lo, MD

Case Presentation
Claudio Tondo, MD, PhD

Panel and Audience Q&A - All Faculty (30 minutes)
Moderator: Roger Winkle, MD
Panel: All Faculty

Noon-1:15 PM
Lunch, Exhibits and Product Theaters

1:15-2:30 PM
STROKE PREVENTION IN AF: SESSION I – SCREENING AND ANTICOAGULATION
Chairs: John Camm, MD and Albert Waldo, MD
All talks 10 minutes & 5 minute Q&A

Consumer Devices for AF Detection and Continuous Monitoring: Current Status and Future Promise
Mintu Turakhia, MD

Update on Device-Detected AF and Stroke Risk as a Function of AF Burden – Clinical Implications (15 minutes)
Daniel Singer, MD

Artificial Intelligence-Enabled ECG Algorithm for Identification During Sinus Rhythm of Patients with AF - Implications for AF Screening and Management of Cryptogenic Stroke
Paul Friedman, MD

Rationale and Feasibility of “As Needed" NOACs for Infrequent AF Episodes Following AF Ablation Guided by Diligent Pulse Monitoring
Francis Marchlinski, MD

Oral Factor XIa Inhibitors: Current & Future Clinical Trials & Potential Advantages over NOACs
Elaine Hylek, MD

2:30-3 PM
STROKE PREVENTION IN AF: SESSION II - LEFT ATRIAL APPENDAGE CLOSURE PROCEDURE
Chairs: Jacqueline Saw, MD and Dhanunjaya Lakkireddy, MD

Case Transmission: Left Atrial Appendage Closure Procedure with New Generation Device
John Foran, MD - Royal Brompton Hospital, London, UK
Moderator: Walid Saliba, MD
Panelists: Dhanunjaya Lakkireddy, MD and Jacqueline Saw, MD

3-3:40 PM
STROKE PREVENTION IN AF: SESSION II - LEFT ATRIAL APPENDAGE CLOSURE AND CAROTID PROTECTION
Chairs: Jacqueline Saw, MD and Dhanunjaya Lakkireddy, MD
All talks 10 minutes with Q&A during panel discussion

Update on Clinical Trials with LAA Closure Devices
Moussa Mansour, MD

Head to Head Study of LAA Closure vs NOAC in High-Risk Patients with AF: PRAGUE 17 Trial
Vivek Reddy, MD

Anticoagulation and Antiplatelet Therapy After LAA Closure: What, When & How Long?
Andrea Natale, MD

FDA Perspective on Left Atrial Appendage Closure Devices for Stroke Prevention
Andrew Farb, MD

3:40-4:10 PM
Break and Exhibits

4:10-5:30 PM
Stroke Prevention in AF: Session II - Left Atrial Appendage Closure (Continued)
Chairs: Jacqueline Saw, MD and Dhanunjaya Lakkireddy, MD
All talks 10 minutes with Q&A during panel discussion

Complications of LAA Closure Devices and Procedures - Prevention and Management
Jacqueline Saw, MD

Future Technologies in Left Atrial Appendage Closure
Dhanunjaya Lakkireddy, MD

Percutaneous Permanent Carotid Filter for Stroke Prevention in AF: CAPTURE and the Ongoing CAPTURE2 Trials
Stuart Connolly, MD

4:40 - 5:30 PM
Panel and Audience Discussion and Q&A (50 minutes) - All Faculty
Chairs: Jacqueline Saw, MD and Dhanunjaya Lakkireddy, MD

5:30 PM
Adjourn

Following Adjournment
AF SYMPOSIUM 25th YEAR EVENING CELEBRATION - Gaylord National Hotel Washington, DC

All Attendees, Industry and Faculty Invited

GENERAL SCIENTIFIC SESSION

6:15-7:15 AM
Morning Coffee

7:15-8:45 AM
REAL-TIME CASE TRANSMISSIONS: NEW DIRECTIONS IN IMAGING, MAPPING AND ABLATION
Panel and Audience Discussions
(All cases 30 minutes)
Chairs: David Keane, MD, PhD; Moussa Mansour, MD; and Jeremy Ruskin, MD
Panel: Pierre Jais, MD, Francis Marchlinski, MD, Andrea Natale, MD, and Vivek Reddy, MD

Non-CME Sponsored Cases

Ultra-Low Temperature Cryoablation for AF
Tom De Potter, MD - OLV Hospital, Aalst, Belgium
On-Site Moderator: Lucas Boersma, MD

Dipole Density Mapping of Atrial Fibrillation
Timothy Betts, MD - Oxford University Hospitals, Oxford, UK

Convergent AF Ablation - Staged PVI After Surgical Posterior Wall Isolation and LAA Closure
Kevin Makati, MD and Andrew Sherman, MD - St. Joseph’s Hospital, Tampa, FL
On-Site Moderator: Felix Yang, MD

8:45-8:55 AM
Break

8:55-10 AM
REAL-TIME CASE TRANSMISSIONS: NEW DIRECTIONS IN IMAGING, MAPPING AND ABLATION
Panel and Audience Discussions
(All Cases 30 Minutes)
Chairs: David Keane, MD, PhD; Moussa Mansour, MD; and Jeremy Ruskin, MD
Panel: Pierre Jais, MD, Francis Marchlinski, MD, Andrea Natale, MD, and Vivek Reddy, MD

CME Cases

High Power Temp Controlled RF Ablation for Non-PV Triggers
Amin Al-Ahmad, MD, Rodney Horton, MD and Andrea Natale, MD - Texas Cardiac Arrhythmia Institute, Austin, TX

Pulsed Field Ablation for Atrial Fibrillation (Prerecorded Case)
Vivek Reddy, MD and Petr Neuzil, MD, PhD - Homolka Hospital, Prague, Czech Republic and Mount Sinai Medical Center, New York, NY

10-10:30 AM
Continental Breakfast and Exhibits

10:30 AM-Noon
STATE OF THE ART IN ADVANCED MAPPING AND CATHETER ABLATION FOR AF: IMPROVING EFFICACY AND EFFICIENCY
Sponsored Session (Non-CME) - Biosense Webster
Chair: Luigi Di Biase, MD, PhD
All talks 10 minutes & 5 minutes Q&A

Introduction (5 minutes)
Luigi Di Biase, MD, PhD

Maximizing the Value of 3-D Mapping and Ultrasound to Reduce Radiation Exposure
Rodney Horton, MD

Advanced Techniques for Mapping Complex Arrhythmias
Elad Anter, MD

Maximizing Lesion Efficacy and Reducing Gaps in AF Ablation
Larry Chinitz, MD

ATTEST Trial - Impact of Catheter Ablation on Progression from Paroxysmal to Persistent AF
Karl-Heinz Kuck, MD

Panel and Audience Discussion and Q&A (25 minutes)
Chair: Luigi DiBiase, MD, PhD
Panel: Elad Anter, MD, Larry Chinitz, MD, Rodney Horton MD, Karl-Heinz Kuck, MD

Noon-1:15 PM
Lunch, Exhibits and Product Theater

1:15-3 PM
ADVANCES IN PULMONARY VEIN ISOLATION (SESSION I) Energy Sources, Delivery Strategies and New Technologies for AF Ablation
Chairs: Hans Kottkamp, MD and Karl-Heinz Kuck, MD
All talks 10 minutes with Q&A during panel discussion

Rates of PV Reconnection: Magnitude of the Problem in 2020
Francis Marchlinski, MD

High-Power Short Duration Ablation Using Currently Available RF Catheters
Andrea Natale, MD

Ultra High-Power, Short Duration Temperature Controlled Ablation with Novel RF Technology
Vivek Reddy, MD

Radiofrequency Balloons for Pulmonary Vein Isolation
Moussa Mansour, MD

Ultra-Low Temperature Linear Cryoablation for AF: Clinical Results
Michel Haissaguerre, MD

Novel Cryoballoon Technologies for AF Ablation - Clinical Outcomes
Bradley Knight, MD

Particle Therapy Ablation - Outcome of Phase I Studies
Douglas Packer, MD

Panel and Audience Discussion and Q&A (35 Minutes) Moderators:
Panel:

3-3:30 PM
Break and Exhibits

3:30-4:30 PM
ADVANCES IN PULMONARY VEIN ISOLATION (SESSION II) Cardiac Pulsed Field Ablation/Irreversible Electroporation
Chairs: Francis Marchlinski, MD and Michel Haissaguerre, MD
All talks 10 minutes with Q&A during panel discussion

Introduction to the Science of Pulsed Field Ablation/Electroporation
Damijan Miklavcic, DSc

Current Status of Pulsed Field Ablation/Cardiac Electroporation for Pulmonary Vein Isolation: Safety and Efficacy
Pierre Jais, MD

Future Directions in Pulsed Field Ablation/Cardiac Electroporation: Linear Lesions and Persistent AF
Vivek Reddy, MD

Panel and Audience Discussion and Q&A (30 Minutes)
Moderators: Francis Marchlinski, MD and Michel Haissaguerre, MD
Panel: Andrea Natale, MD Damijan Miklavcic, DSc, Pierre Jais, MD, Vivek Reddy, MD

4:30-6:30 PM
LATE BREAKING CLINICAL TRIALS AND FIRST REPORT CLINICAL INVESTIGATIONS
All talks 10 minutes & 5 minutes Q&A
Chair: Jeremy Ruskin, MD

Focal Source and Trigger (FaST) Mapping in Atrial Fibrillation: Randomized controlled trial evaluating a novel adjunctive ablation strategy
Vijay Chauhan, MD FRCPC and Co-Authors
Peter Munk Cardiac Center, Toronto General Hospital, Toronto, ON, Canada

The Value of Extensive Catheter Linear Ablation on Persistent Atrial Fibrillation (The CLEAR-AF Study)
Feng Hu, MD and Co-Authors Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Arctic Front Advance Cryoballoon Ablation for Persistent Atrial Fibrillation: 12 Month Efficacy and Safety Results from the Global Prospective Multicenter STOP PERSISTENT AF Study
Hugh Calkins, MD and Co-Authors
Johns Hopkins, Baltimore, MD, USA

Pulmonary Vein Isolation and Linear Lesion Durability of a Lattice-Tip Temperature-Controlled Radiofrequency Ablation Catheter: A First-in-Human Trial
Vivek Y. Reddy, MD and Co-Authors
Mount Sinai Hospital, New York, NY, USA

First Report from PersAFOne: Pulsed Field Ablation to Treat Persistent Atrial Fibrillation with Pulmonary Vein Isolation Plus Posterior Wall Ablation
Vivek Y. Reddy, MD and Co-Authors Mount Sinai Hospital, New York, NY, USA

The Safety and Effectiveness of Pulmonary Vein Isolation with Standardized VISITAG SURPOINT™ Workflow
Mattias Duytschaever, MD and Co-Authors
AZ St Jan Brugge, Belgium

Esophageal Protection During AF Ablation: a Double-Blinded Randomized Clinical Trial
Mark M. Gallagher, MD and Co-Authors
St. George's University of London, London, UK

BEST ABSTRACT AWARD AND PRESENTATION
10 Minutes

Pulsed Field Ablation vs Radiofrequency Ablation: Esophageal Effects in a Novel Preclinical Model
Jacob Koruth, MD and Co-Authors
Mount Sinai Medical Center, New York, NY, USA

6:30 PM
Adjourn

GENERAL SCIENTIFIC SESSION

7-8 AM
Morning Coffee

8-9:30 AM
BEYOND PVI - ANATOMICAL VS ELECTROPHYSIOLOGICAL TARGETS FOR AF ABLATION (Session I)
All talks 10 minutes & 5 minute Q&A
Chairs: David Wilber, MD and Douglas Packer, MD

Repetitiveness of Spatiotemporal Patterns of AF As Determinant of AF Stability
Ulrich Schotten, MD, PhD

Using Instantaneous Amplitude and Frequency Modulation to Detect the Footprint of Stable Driver Regions as Targets for Ablation of Persistent AF
Jose Jalife, MD

Comparison of High Resolution Experimental Optical Mapping and Catheter Mapping of AF
Hiroshi Nakagawa, MD, PhD

De-Channeling Scar During Redo AF and Flutter Ablations: New Substrate-Based Approach
Nassir Marrouche, MD

How to Modify the Atrial Substrate in Patients with Longstanding Persistent AF
Young-Hoon Kim, MD, PhD

Computationally Guided Personalized Targeted Ablation for Persistent AF
Natalia Trayanova, PhD

9:30-10:30 AM
Continental Breakfast and Exhibits

10:30-Noon
BEYOND PVI - ANATOMICAL VS ELECTROPHYSIOLOGICAL TARGETS FOR AF ABLATION (Session II)
All talks 10 minutes & 5 minute Q&A

Comparison of Anatomical vs. Electrophysiological Procedure for Persistent AF - A Multicenter Study
Michel Haissaguerre, MD

Left Atrial Appendage Isolation - Impact on Long-Term Arrhythmia Recurrence and Systemic Thromboembolism
Andrea Natale, MD

Recent Trials in Persistent AF: Toward a Uniform Strategy or Individualized Approaches?
David Wilber, MD

Panel and Audience Discussion and Q&A (45 minutes) - All Faculty from Sessions I & II
Chairs: David Wilber, MD and Douglas Packer, MD

Noon-12:30 PM
IMPROVING THE SAFETY, EFFECTIVENESS AND EFFICIENCY OF AF ABLATION
Chair: Isabel Deisenhofer, MD
All talks 10 minutes & 5 minutes Q&A

New Data Regarding Esophageal Injury with High-Power-Short-Duration Ablation
Thomas Deneke, MD

How to Improve the Safety, Efficiency and Cost of AF Ablation Procedures
Isabel Deisenhofer, MD

12:30 PM
Working Lunch Buffet in Meeting Hall

12:45 - 2 PM
OUTCOMES TRIALS IN ATRIAL FIBRILLATION ABLATION
Results, Implications for Clinical Practice and Future Studies
Chairs: Hugh Calkins, MD and Nassir Marrouche, MD
All talks 10 minutes & 5 minute Q&A

New Output from the CABANA Trial: The Effect of NSR Regardless of Treatment Strategy
Douglas Packer, MD

Outcomes and Clinical Implications of AF Ablation Trials in Patients with Heart Failure
Nassir Marrouche, MD

Recurrence of AF 10 years After Index PVI and Proven PV Isolation: Is This A New Disease?
Andrea Natale, MD

New Approaches to Measuring Outcomes of AF Ablation - Is a 30-Second Recurrence a Meaningful Endpoint?
Hugh Calkins, MD

What CABANA Has Taught Us: A Regulatory Perspective
Jun Dong, MD

2 - 3:30 PM
CHALLENGING CASES IN AF MANAGEMENT: ANTICOAGULATION, ANTIARRHYTHMIC DRUGS AND CATHETER ABLATION FOR AF
Panel and Audience Discussion (10 minutes per case)
Moderator: Eric Prystowsky, MD
Case Presenters: Luigi Di Biase, MD, PhD, Mahmut Gurol, MD, MSc, David Keane, MD, PhD, Douglas Packer, MD, Jeremy Ruskin, MD

3:30 PM
Adjourn

REGISTRATION & BADGE PICK-UP

Wednesday, January 22
Noon - 6:30 PM

Thursday, January 23
Friday, January 24
Saturday, January 25
6:30 AM - Close

EXPO HALL OPENS

Thursday, January 23 at 9 AM